Our research in biological and chemical detection leverages our work in materials and in integrated devices. Frequently, advances in materials or in devices directly translate to novel strategies for bio/chem detection. Additionally, we often collaborate with other research groups in this area, sharing our expertise.
We have several projects investigating routes to efficiently and controllably attach smart materials to the surface of integrated optical devices, either through grafting strategies (for polymers) or controlled growth methods (for semiconductor structures).
We are actively building several new biodetection and biocharacterization instruments for applications in low resource settings (e.g. malaria detection) and early cancer detection.
Leveraging several of our recently invented smart materials, we are creating flexible, wearable sensors for UV monitoring and environmental monitoring.
Lipid Bilayers and Cell Membrane Dynamics
We have a significant effort studying how the cell membrane is disrupted (porated) in response to a variety of inputs (electrical, mechanical). This work includes using model systems (lipid bilayers) and cells (cancer and neurons). We perform both label-free experiments and imaging methods, and the work is complemented with molecular dynamics modeling.
We are performing FEM modeling of several of the parameters of our sensor systems, such as binding kinetics at the sensor surface and mass transport to the sensing device.
Different parts of these research efforts are performed as collaborations with the following research groups:
Recent papers in this area:
S. Mehrabani, P. Kwong, M. Gupta, A. M. Armani, “Hybrid microcavity humidity sensor”, Applied Physics Letters 102, 241101 (2013).